Interstitial Cystitis

An Evening with Dr. Robert Moldwin
New, Emerging Therapies for Interstitial Cystitis


IC/PBS is a condition of increased bladder sensitivity. Its diagnosis is primarily made on the basis of typical symptoms and the lack of other significant bladder problems such as a bladder infection or cancer. IC/PBS is more common in women, but recent evidence suggests that the prevalence in men is much higher than previously thought.

The symptoms of IC/PBS may include:

  • Urinary frequency. Small volumes are typically voided. Patients usually awaken at night to urinate.
  • Urinary urgency. Patients usually need to seek bathroom facilities quickly due to mounting discomfort, not the sensation that they might leak urine.
  • Pelvic pain or discomfort. This often changes as the bladder fills and empties.

Other problems frequently encountered by the IC/PBS patient include:

  • Pain associated with sexual intercourse
  • Symptoms worsened by various foods and beverages
  • Other co-existing problems such as environmental allergies, irritable bowel syndrome, fibromyalgia, skin sensitivity, and vulvodynia (vulvar pain)
  • Hesitation or interruption of the urine stream
  • Constipation
  • The sensation of needing to urinate almost immediately after urinating.
  • Symptoms that vary with the menstrual cycle.

IC/PBS can be broken down into two major categories:

  1. "Classic" disease. This form of IC/PBS is associated with visible inflammation of the bladder wall. Lesions called "Hunner's ulcers" or "Hunner's patches" can be seen when the bladder is examined. Only about 5% of all patients have this type of disease.

  2. "Non-classical" disease. Patients with this condition have many symptoms, but examination of the bladder surface shows no obvious inflammation. Most patients with IC/PBS have non-classical disease.